UNNE

Catálogo Bibliográfico
Red de Bibliotecas UNNE

Red de Bibliotecas
Ito, Yuki
  Efectos antimicrobianos y antibiofilm del ácido abiético sobre Streptococcus mutans cariogénico
  En: Odontology / The Society of the Nippon Dental University; odo, v.108 no1. -- Vol. 108, no. 1 (January, 2020). -- Tokyo : Springer, 2001

  Dental caries is a type of oral microbiome dysbiosis and biofilm infection that affects oral and systemic conditions. For healthy life expectancy, natural bacteriostatic products are ideal for daily and lifetime use as anti-oral infection agents. This study aimed to evaluate the inhibitory effects of abietic acid, a diterpene derived from pine rosin, on the in vitro growth of cariogenic bacterial species, Streptococcus mutans. The effective minimum inhibitory concentration of abietic acid was determined through observation of S. mutans growth, acidification, and biofilm formation. The inhibitory effects of abietic acid on the bacterial membrane were investigated through the use of in situ viability analysis and scanning electron microscopic analysis. Cytotoxicity of abietic acid was also examined in the context of several human cell lines using tetrazolium reduction assay. Abietic acid was found to inhibit key bacterial growth hallmarks such as colony forming ability, adenosine triphosphate activity (both planktonic and biofilm), acid production, and biofilm formation. Abietic acid was identified as bacteriostatic, and this compound caused minimal damage to the bacterial membrane. This action was different from that of povidone-iodine or cetylpyridinium chloride. Additionally, abietic acid was significantly less cytotoxic compared to povidone-iodine, and it exerted lower toxicity towards epithelial cells and fibroblasts compared to that against monocytic cells. These data suggest that abietic acid may prove useful as an antibacterial and antibiofilm agent for controlling S. mutans infection.
  ISSN: 16181247

  1. ACIDO ABIETICO; 2. STREPTOCOCCUS MUTANS; 3. ANTIMICROBIANO; 4. BIOFILM ORAL; 5. TERPENOS I. Ito, Takashi II. Yamashiro, Keisuke III. Mineshiba, Fumi IV. Hirai, Kimito V. Omori, Kazuhiro VI. Yamamoto, Tadashi VII. Takashiba, Shogo

Dirección: Av. Las Heras 727
Campus UNNE Resistencia, Chaco. CP 3500.
E-Mail: contacto@bib.unne.edu.ar
Nos encontramos dando servicios
únicamente en forma virtual

Pérgamo OPAC Web

Formulario para Solicitud de Material

Ito, Yuki
Efectos antimicrobianos y antibiofilm del ácido abiético sobre Streptococcus mutans cariogénico
En: Odontology / The Society of the Nippon Dental University; odo, v.108 no1. -- Vol. 108, no. 1 (January, 2020). -- Tokyo : Springer, 2001

Dental caries is a type of oral microbiome dysbiosis and biofilm infection that affects oral and systemic conditions. For healthy life expectancy, natural bacteriostatic products are ideal for daily and lifetime use as anti-oral infection agents. This study aimed to evaluate the inhibitory effects of abietic acid, a diterpene derived from pine rosin, on the in vitro growth of cariogenic bacterial species, Streptococcus mutans. The effective minimum inhibitory concentration of abietic acid was determined through observation of S. mutans growth, acidification, and biofilm formation. The inhibitory effects of abietic acid on the bacterial membrane were investigated through the use of in situ viability analysis and scanning electron microscopic analysis. Cytotoxicity of abietic acid was also examined in the context of several human cell lines using tetrazolium reduction assay. Abietic acid was found to inhibit key bacterial growth hallmarks such as colony forming ability, adenosine triphosphate activity (both planktonic and biofilm), acid production, and biofilm formation. Abietic acid was identified as bacteriostatic, and this compound caused minimal damage to the bacterial membrane. This action was different from that of povidone-iodine or cetylpyridinium chloride. Additionally, abietic acid was significantly less cytotoxic compared to povidone-iodine, and it exerted lower toxicity towards epithelial cells and fibroblasts compared to that against monocytic cells. These data suggest that abietic acid may prove useful as an antibacterial and antibiofilm agent for controlling S. mutans infection.
ISSN: 16181247

1. ACIDO ABIETICO; 2. STREPTOCOCCUS MUTANS; 3. ANTIMICROBIANO; 4. BIOFILM ORAL; 5. TERPENOS I. Ito, Takashi II. Yamashiro, Keisuke III. Mineshiba, Fumi IV. Hirai, Kimito V. Omori, Kazuhiro VI. Yamamoto, Tadashi VII. Takashiba, Shogo
Solicitante: